Distinct Idiotypes of Insulin Autoantibody in Autoimmune Polyendocrine Syndrome Type 2 and Childhood Onset Type 1 Diabetes
نویسندگان
چکیده
منابع مشابه
Autoimmune polyendocrine syndrome type 1 and NALP5, a parathyroid autoantigen.
BACKGROUND Autoimmune polyendocrine syndrome type 1 (APS-1) is a multiorgan autoimmune disorder caused by mutations in AIRE, the autoimmune regulator gene. Though recent studies concerning AIRE deficiency have begun to elucidate the molecular pathogenesis of organ-specific autoimmunity in patients with APS-1, the autoantigen responsible for hypoparathyroidism, a hallmark of APS-1 and its most c...
متن کاملOral microbiota in autoimmune polyendocrine syndrome type 1
Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Autoimmune Regulator gene. The phenotypic expression is highly variable and includes disease manifestations in the oral cavity, including mucocutaneous candidiasis. Increasing evidence suggests a potential role of the skin, oral and gut microbiotas in the pathogenesis of au...
متن کاملPituitary autoantibodies in autoimmune polyendocrine syndrome type 1.
Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies (Aabs) toward intracellular enzymes are a hallmark for APS1 and serve as diagnostic markers and predictors for disease manifestations. In this study, we aimed to identify pituitary autoantigens in patients with APS1. A pitu...
متن کاملBirth Weight and Childhood Onset Type 1 Diabetes: A Case-Control Study in Shiraz, South of Iran
To determine the relation between birth weight and age of presentation of type 1 diabetes and assess its risk factors, a case-control study was done on all diabetic patients under the age of 15, who were registered in Shiraz Diabetic Center or admitted in Namazi Hospital. A case group of 87 diabetic patients were matched with a control group of 100 healthy individuals. Birth weight ≥ 4kg was de...
متن کاملSerological proteome analysis reveals new specific biases in the IgM and IgG autoantibody repertoires in autoimmune polyendocrine syndrome type 1.
OBJECTIVE Autoimmune polyendocrine syndrome type 1 (APS 1) is caused by mutations in the AIRE gene that induce intrathymic T-cell tolerance breakdown, which results in tissue-specific autoimmune diseases. DESIGN To evaluate the effect of a well-defined T-cell repertoire impairment on humoral self-reactive fingerprints, comparative serum self-IgG and self-IgM reactivities were analyzed using b...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2004
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2004-0489